Synopsis of resource:
This article gives insight into the pathophysiological basis of early recognition of Autism spectrum disorder. The author hypothesizes that altered dissolution of the temporary neural structures in the fronto-temporo-parietal cortex and the cerebellum determines the appearance of the social and motor signs of Autism in children as early as 6 and 12 months of age. The putative neural substrate for early signs, specifically, altered social communication, sensory processing and motor development have been proposed.
Key learning outcomes
- The early social and motor signs of autism spectrum disorder emerge between the ages of 6 and 12months.
- Altered dissolution of transient brain structures in the fronto-temporo-parietal cortex and cerebellum may underlie the emergence of these early signs.
Author
Mijna Hadders-Algra MD, PhD is emeritus professor of Developmental Neurology in Groningen, the Netherlands. Her research deals in particular with pathophysiology of neurodevelopmental disorders, early detection of neurodevelopmental disabilities and early intervention. The research on pathophysiology focuses on general movements and postural control, that on early detection on the general movements, the Infant Motor Profile and Standardized Infant NeuroDevelopmental Assessment. Together with Tineke Dirks and Schirin Akhbari Ziegler she developed the family-centered early intervention program COPCA (COPing with and CAring for infants with special needs).
She (co)authored >300 publications in peer reviewed journals, and she authored/edited eight books, including a book on Early Detection and Early Intervention in Developmental Motor Disorders. She frequently teaches and lectures about early detection and early intervention worldwide.
